MKS Iuventa Michalovce have been part of European competitions since 2003/04, whether in qualifications, group phases or knock-out stages, missing out only the 2017/18 season.

In the 2022/23 season, the Slovakian club are competing in the EHF European Cup Women and by reaching the semi-finals, they have created one of the club's biggest successes in Europe, according to centre back Patrícia Wollingerová.